Engineering strategies to overcome the current roadblocks in CAR T cell therapy | Nature Reviews Clinical Oncology
Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domain
Hypothesized Models of the CD28 and CD8a Hinge Regions (A) The... | Download Scientific Diagram
Crystals | Free Full-Text | Crystal Structure of a Chimeric Antigen Receptor (CAR) scFv Domain Rearrangement Forming a VL-VL Dimer
T cell receptor, CD8 co-receptor and MHC class I molecule. The T cell... | Download Scientific Diagram
Frontiers | Reducing Hinge Flexibility of CAR-T Cells Prolongs Survival In Vivo With Low Cytokines Release
CD8 stalk sequences and modeling of a novel CD8ab-pMHC binding mode.... | Download Scientific Diagram
Cancers | Free Full-Text | Engineering Solutions for Mitigation of Chimeric Antigen Receptor T-Cell Dysfunction
Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation | bioRxiv
Engineering and Design of Chimeric Antigen Receptors - ScienceDirect
EP3115373A1 - Chimeric antigen receptors with an optimized hinge region - Google Patents
Activity of sCAR hinge designs. (A) Cytotoxicity of sCAR-T cells with... | Download Scientific Diagram
JCI Insight - Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization
Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse - Biology of Blood and Marrow Transplantation
Frontiers | Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells
Fine Molecular Tuning of Chimeric Antigen Receptors through Hinge Length Optimization | bioRxiv
Engineering and Design of Chimeric Antigen Receptors - ScienceDirect
Cells | Free Full-Text | Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold
Fine Molecular Tuning of Chimeric Antigen Receptors through Hinge Length Optimization | bioRxiv
EP3115373A1 - Chimeric antigen receptors with an optimized hinge region - Google Patents
Frontiers | The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28
Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells | Journal of Hematology & Oncology | Full Text
CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8+ T-cell Responses - ScienceDirect
Cells | Free Full-Text | Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold
The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer | Nature Communications
